Not known Factual Statements About modafinil dosage
Not known Factual Statements About modafinil dosage
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cyclophosphamide will enhance the degree or result of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unfamiliar.
modafinil will enhance the level or impact of pantoprazole by influencing hepatic enzyme CYP2C19 metabolism. Slight/Importance Unidentified. Web impact on pantoprazole actions mysterious as a result of opposing consequences of CYP450 enzymes; watch
Avoid coadministration of delicate CYP3A4 substrates with ivosidenib or change with choice therapies. If coadministration is unavoidable, keep track of patients for lack of therapeutic outcome of these medicines.
istradefylline will boost the amount or effect of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
Provigil is used to take care of excessive sleepiness because of rest apnea, narcolepsy, or shift get the job done slumber condition.
Outcome of coadministration of a twin CYP3A4 and CYP2C19 inhibitor with fedratinib hasn't been examined.
Talk to your health practitioner about what to do for those who miss out on a dose of Provigil. Stay away from taking the drugs If you don't intend to be awake for many hours. Skip the missed dose if it is sort of bedtime. Usually do not get added medicine to create up the missed dose.
Stay clear of or substitute Yet another drug for these medications when achievable. Evaluate for loss of therapeutic effect if medication needs to be coadministered. Alter dose Based on prescribing info if essential.
In Australia, modafinil is regarded as a Timetable four prescription-only medicine. Therefore it is a drug with a perceived lower potential for abuse and minimal chance of dependence; continue to, the use of Plan 4 medicines in Australia is restricted to individuals who have a valid prescription from a health-related practitioner; import from overseas is illegitimate.[169] copyright[edit]
triclabendazole will raise the level or outcome of modafinil by impacting hepatic enzyme CYP2C19 metabolism.
Stiripentol is actually a CYP3A4 inhibitor and inducer. Keep track of CYP3A4 substrates coadministered with stiripentol for elevated or decreased outcomes. CYP3A4 substrates may well call for dosage adjustment.
No certain antidote exists with the toxic outcomes of the PROVIGIL overdose. These overdoses must be managed with largely supportive treatment, which includes cardiovascular checking.
Blood levels of cyclosporine might be decreased when utilized with PROVIGIL. Monitoring of circulating cyclosporine concentrations and suitable dosage adjustment for cyclosporine ought to be regarded as when utilized concomitantly with PROVIGIL.
Severe hepatic impairment: A lowered dose is suggested; on the other hand, no certain guidelines click here are actually instructed in the manufacturer solution details. Use with warning.